用纳米药物的纳米颗粒获得整个育雏血脑屏障的纳米药物方法

Title:Nanomedicinal Approach of Getting Across the Brood-Brain Barrier with Nanomedicinal Nanoparticles

Volume: 22 Issue: 37

Author(s): D. Psimadas, T. Tsotakos, E. Fragogeorgi and G. Loudos

Affiliation:

关键词: 血脑屏障，药物发展，纳米药物，纳米粒子，正离子发射技术，发射性药物，单光子发射计算机断层扫描。

摘要: Passage into the brain has always been a major challenge for medicine in order to treat malfunctions of the central nervous system (CNS). The blood-brain-barrier (BBB) is a physical obstacle that controls the entrance of substances -including pharmaceuticals- into the brain. The application of nanotechnology in medicine, namely nanomedicine, is rapidly evolving and opens new prospects for brain imaging and drug delivery into the brain. Nanomedicine when combined with nuclear medicine can offer new, promising and innovative means towards this direction through radiolabeled nanoparticles.

Nanoparticles radiolabeled with β^-, γ- or β⁺-emitters can cross the BBB and play major role in CNS imaging and/or drug delivery.

Cite this article as:

D. Psimadas, T. Tsotakos, E. Fragogeorgi and G. Loudos , Nanomedicinal Approach of Getting Across the Brood-Brain Barrier with Nanomedicinal Nanoparticles, Current Medicinal Chemistry 2015; 22 (37) . https://dx.doi.org/10.2174/0929867322666151029105302