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Current Molecular Medicine


ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Cell-in-cell phenomenon: A New Paradigm in Life Sciences.

Author(s): X. Wang

Volume 15, Issue 9, 2015

Page: [810 - 818] Pages: 9

DOI: 10.2174/1566524015666151026095730

open access plus


Cell-in-cell, a phenomenon characterized by one or more viable cells entering actively into another cell, was observed more than a century and has only attracted more attention in recent years and is becoming a new hot topic in the biological field, owing its biological significance in evolutionary as well as physiological and pathological relevance in development, homeostasis and diseases. In this paper we focus on the diversity, evolutionary conservatism and clinical implication of cell-in-cell as well as latest opinions on the research strategies. Based on the findings from our laboratory and other research groups three working models of cell-in-cell are also proposed.

Keywords: Cell-in-cell, cell-in-cell death, cell model, cell diversity, cell evolution.

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