Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

Title:Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

Volume: 13 Issue: 6

Author(s): Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich

Affiliation:

• Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary.,Hungary

Keywords: Pamidronic acid, best synthesis, additive, ionic liquids, intermediate.

Abstract: An efficient method was developed for the synthesis of pamidronic acid involving the reaction of β-alanine with three equivalents of phosphorus trichloride and two equivalents of phosphorous acid at 75 °C in the presence of 0.3 or 0.6 equivalents of [BMIM][PF₆] as an additive.

Cite this article as:

Grun Alajos, Illés Nagy Dávid, Garadnay Sándor, Greiner István and Keglevich Gyorgy, Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive, Letters in Drug Design & Discovery 2016; 13(6) . https://dx.doi.org/10.2174/1570180812666151022221805