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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

Author(s): Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich

Volume 13, Issue 6, 2016

Page: [475 - 478] Pages: 4

DOI: 10.2174/1570180812666151022221805

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An efficient method was developed for the synthesis of pamidronic acid involving the reaction of β-alanine with three equivalents of phosphorus trichloride and two equivalents of phosphorous acid at 75 °C in the presence of 0.3 or 0.6 equivalents of [BMIM][PF6] as an additive.

Keywords: Pamidronic acid, best synthesis, additive, ionic liquids, intermediate.

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