Synthesis and Biological Evaluation of Some New Indolizine Derivatives as Antitumoral Agents

Title:Synthesis and Biological Evaluation of Some New Indolizine Derivatives as Antitumoral Agents

Volume: 13 Issue: 6

Author(s): Liliana Lucescu, Elena Bîcu, Dalila Belei, Joelle Dubois and Alina Ghinet

Affiliation:

Keywords: Indolizine, farnesyltransferase, anticancer agent.

Abstract: A new series of indolizine derivatives were synthesized and screened for the antiproliferative potential against NCI 60 tumor cell line panel. The results of the study revealed a selective and good antitumor growth inhibitory activity against SNB-75 CNS cancer cell line for 1-cyanoindolizine derivative 10b. Moreover, a supplementary in vitro biological evaluation showed that compound 9d exhibited a significant farnesyltransferase inhibition activity (IC₅₀ = 1.07 ± 0.34 µM) and could represent a lead for the development of new antitumoral chemical entities.

Cite this article as:

Lucescu Liliana, Bîcu Elena, Belei Dalila, Dubois Joelle and Ghinet Alina, Synthesis and Biological Evaluation of Some New Indolizine Derivatives as Antitumoral Agents, Letters in Drug Design & Discovery 2016; 13 (6) . https://dx.doi.org/10.2174/1570180812666151022221628