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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Herb-Drug Interactions: An Evidence Based Approach

Author(s): P. D. Coxeter, A. J. McLachlan, C. C. Duke and B. D. Roufogalis

Volume 11 , Issue 11 , 2004

Page: [1513 - 1525] Pages: 13

DOI: 10.2174/0929867043365198

Price: $65


The increasing use of herbal medicinal products (HMPs) in the community where people are also receiving prescription medicines suggests that adverse herb-drug interactions may be of significant public health consequence. The evidence available to guide practitioners in decision making is complex and consists of a range of sources including adverse event database entries, spontaneous or case reports, in vivo and in vitro drug metabolism studies, and in vivo drug interaction studies in healthy subjects and patients. In the absence of further rigorous studies to assess the clinical significance of herb-drug interactions, an evidencebased appraisal of the current literature is essential to guide practitioners involved in patient care.

Keywords: herb-drug interactions, pharmacokinetics, pharmacodynamics, hypericum perforatum, panax ginseng, ginkgobiloba, glycyrrhiza glabra

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