摘要
氧化应激在不同疾病的致病因素中起着重要的作用。抗氧化剂通过清除氧自由基和活性氧来使细胞和组织免受氧化应激。这些抗氧化剂可能是内源性的或外源性的。植物被认为是强大的潜在外源性抗氧化剂资源。黄芪属(种),尤其是黄芪,在中国传统药物中有着很长的药物使用史。特别的是,黄芪种(黄芪)干燥根的成分在各种氧化应激相关疾病模型中表现出强大的心脏,大脑,肾脏,肠,肝脏和肺部保护作用。黄芪中不同的分离成分,例如黄芪总苷,黄酮和多糖通过抗氧化机制也表现出强大的组织保护作用。这篇文献综述了黄芪的抗氧化效益和其分离成分的组织保护作用,以及有抗氧化活性的各种成分的鉴定。
关键词: 黄芪属,黄芪,抗氧化剂,黄芪总苷,心血管保护,缺血-再灌注,肾保护
Current Drug Targets
Title:The Antioxidant Effects of Radix Astragali (Astragalus membranaceus and Related Species) in Protecting Tissues from Injury and Disease
Volume: 17 Issue: 12
Author(s): Muhammad Shahzad, Arham Shabbir, Ken Wojcikowski, Hans Wohlmuth, Glenda C. Gobe
Affiliation:
关键词: 黄芪属,黄芪,抗氧化剂,黄芪总苷,心血管保护,缺血-再灌注,肾保护
摘要: Oxidative stress plays a key role in the pathogenesis of various diseases. Antioxidants protect the cells and tissues from oxidative stress by scavenging free radicals and reactive oxygen species. These antioxidants may be endogenous or exogenous. Plants are considered as potential and powerful exogenous source of antioxidants. Astragalus species (spp.), especially Astragalus membranaceus, have a long history of medicinal use in traditional Chinese medicine. Specifically, constituents of the dried roots of Astragalus spp. (Radix Astragali) provide significant protection against heart, brain, kidney, intestine, liver and lung injury in various models of oxidative stress-related disease. Different isolated constituents of Astragalus spp., such as astragalosides, flavonoids and polysaccharides also displayed significant prevention of tissue injury via antioxidant mechanisms. In this article, the antioxidant benefits of Astragalus spp. and its isolated components in protecting tissues from injury are reviewed, along with identification of the various constituents that possess antioxidant activity.
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Muhammad Shahzad, Arham Shabbir, Ken Wojcikowski, Hans Wohlmuth, Glenda C. Gobe , The Antioxidant Effects of Radix Astragali (Astragalus membranaceus and Related Species) in Protecting Tissues from Injury and Disease, Current Drug Targets 2016; 17 (12) . https://dx.doi.org/10.2174/1389450116666150907104742
DOI https://dx.doi.org/10.2174/1389450116666150907104742 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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