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Current Stem Cell Research & Therapy

Editor-in-Chief

ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

The Role of Bioreactors in Ligament and Tendon Tissue Engineering

Author(s): James Mace, Andy Wheelton, Wasim S. Khan and Sanj Anand

Volume 11, Issue 1, 2016

Page: [35 - 40] Pages: 6

DOI: 10.2174/1574888X10666150904113827

Price: $65

Abstract

Bioreactors are pivotal to the emerging field of tissue engineering. The formation of neotissue from pluripotent cell lineages potentially offers a source of tissue for clinical use without the significant donor site morbidity associated with many contemporary surgical reconstructive procedures. Modern bioreactor design is becoming increasingly complex to provide a both an expandable source of readily available pluripotent cells and to facilitate their controlled differentiation into a clinically applicable ligament or tendon like neotissue. This review presents the need for such a method, challenges in the processes to engineer neotissue and the current designs and results of modern bioreactors in the pursuit of engineered tendon and ligament.

Keywords: Bioreactors, flow perfusion, ligament, rotating wall, spinner flasks, tendon.


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