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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Immobilization of Aldolase for C-C Bond Formation

Author(s): Caio C. Aragon, Jose M. Palomo, Marco Filice and Cesar Mateo

Volume 20, Issue 11, 2016

Page: [1243 - 1251] Pages: 9

DOI: 10.2174/1385272819666150831202640

Price: $65


The aldol reactions catalyzed by aldolases are an important tool in the synthesis of different products or building blocks. However, despite its advantages, aldolases, as enzymes, have some troubles as their low activity against synthetic substrates or the low stability, doing difficult their application. There are different tools to improve the properties of this enzyme such as directed mutagenesis, directed evolution or the immobilization methods. The immobilization not only is able to improve the properties of the enzymes but also permits the reuse of the catalysts. This review is focused on the immobilization of different aldolases using different methodologies.

Keywords: Aldolase, enzyme immobilization, solid supports.

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