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Current Neuropharmacology

Rome
(Italy)

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

The Antidepressant-like Effects of Estrogen-mediated Ghrelin

Author(s): Pu Wang, Changhong Liu, Lei Liu, Xingyi Zhang, Bingzhong Ren and Bingjin Li

Volume 13 , Issue 4 , 2015

Page: [524 - 535] Pages: 12

DOI: 10.2174/1570159X1304150831120650

Price: $65

Abstract

Ghrelin, one of the brain-gut peptides, stimulates food-intake. Recently, ghrelin has also shown to play an important role in depression treatment. However, the mechanism of ghrelin’s antidepressant-like actions is unknown. On the other hand, sex differences in depression, and the fluctuation of estrogens secretion have been proved to play a key role in depression. It has been reported that women have higher level of ghrelin expression, and ghrelin can stimulate estrogen secretion while estrogen acts as a positive feedback mechanism to up-regulate ghrelin level. Ghrelin may be a potential regulator of reproductive function, and estrogen may have additional effect in ghrelin’s antidepressantlike actions. In this review, we summarize antidepressant-like effects of ghrelin and estrogen in basic and clinical studies, and provide new insight on ghrelin’s effect in depression.

Keywords: Depression, estrogen, ghrelin, mechanism.

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