Abstract
We describe here a simple protocol for the synthesis of 4-(arylsulfenyl)-1H-pyrazoles by copper-catalyzed cyclocondensation and direct C–H bond sulfenylation reactions. The products were obtained in good yields by the reaction of a range of 1,3-diketones, arylhydrazines and arylthiols, using catalytic amount of CuI. This One-Pot Multicomponent protocol is an efficient method to synthesize new compounds with potential application in biological studies and material sciences.
Keywords: Catalysis, copper, green chemistry, heterocycles, multicomponent, pyrazoles, sulfur.
Current Organic Synthesis
Title:Copper-Catalyzed One-Pot Multicomponent Reactions: Synthesis of 4-Arylsulfenyl Pyrazoles
Volume: 12 Issue: 6
Author(s): Daniela H. Oliveira, Diego Alves, Raquel G. Jacob and Maurício C. D. F. Xavier
Affiliation:
Keywords: Catalysis, copper, green chemistry, heterocycles, multicomponent, pyrazoles, sulfur.
Abstract: We describe here a simple protocol for the synthesis of 4-(arylsulfenyl)-1H-pyrazoles by copper-catalyzed cyclocondensation and direct C–H bond sulfenylation reactions. The products were obtained in good yields by the reaction of a range of 1,3-diketones, arylhydrazines and arylthiols, using catalytic amount of CuI. This One-Pot Multicomponent protocol is an efficient method to synthesize new compounds with potential application in biological studies and material sciences.
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Cite this article as:
Oliveira H. Daniela, Alves Diego, Jacob G. Raquel and Xavier C. D. F. Maurício, Copper-Catalyzed One-Pot Multicomponent Reactions: Synthesis of 4-Arylsulfenyl Pyrazoles, Current Organic Synthesis 2015; 12 (6) . https://dx.doi.org/10.2174/157017941206150828114009
DOI https://dx.doi.org/10.2174/157017941206150828114009 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
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