未来的合成疫苗佐剂TLR激动剂的结构性质

Title:Structural Properties of Potential Synthetic Vaccine Adjuvants - TLR Agonists

Volume: 22 Issue: 29

Author(s): Jan Honegr, Ondrej Soukup, Rafael Dolezal, David Malinak, Marek Penhaker, Roman Prymula and Kamil Kuca

Affiliation:

关键词: 免疫佐剂，TLR，疫苗，SMIP，先天免疫，药物设计，靶向，Toll样受体。

摘要: Toll like receptors (TLRs) are a family of transmembrane proteins which play a key role in innate immunity. When TLRs come into contact with a potential threat, they initiate a signaling cascade leading to release of cytokines and chemokines, maturation of antigen presenting cells and immune activation. Molecules which can activate TLRs may be utilized for vaccine development and act as vaccine adjuvants. Adjuvants can facilitate production of more effective vaccines based on antigens produced by recombinant techniques or by DNA vaccines, which are often poorly immunogenic since they lack the endogenous innate immunostimulatory components of the pathogen. In this paper the structural properties of such prospective compounds are thoroughly discussed.

Cite this article as:

Jan Honegr, Ondrej Soukup, Rafael Dolezal, David Malinak, Marek Penhaker, Roman Prymula and Kamil Kuca , Structural Properties of Potential Synthetic Vaccine Adjuvants - TLR Agonists, Current Medicinal Chemistry 2015; 22 (29) . https://dx.doi.org/10.2174/0929867322666150821094634