T-cell Activation Induces Dynamic Changes in miRNA Expression Patterns in CD4 and CD8 T-cell Subsets

Author(s): Nato Teteloshvili, Katarzyna Smigielska-Czepiel, Bart-Jan Kroesen, Elisabeth Brouwer, Joost Kluiver, Annemieke M. H. Boots and Anke van den Berg

Volume 4 , Issue 2 , 2015

Page: [117 - 122] Pages: 6

DOI: 10.2174/2211536604666150819194636

Price: $65

Abstract

T-cell activation affects microRNA (miRNA) expression in T-cell subsets. However, little is known about the kinetics of miRNA regulation and possible differences between CD4 and CD8 T cells. In this study we set out to analyze the kinetics of activation-induced expression regulation of twelve pre-selected miRNAs. The dynamics of the expression of these miRNAs was studied in sorted CD4 and CD8 CD45RO- T cells of healthy individuals stimulated with

Keywords: Activation, antibodies, immune, microRNA, miRNA regulation, T cell.


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