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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Assembly of Quinoline, Triazole and Oxime Ether in a Single Molecular Entity: A Greener and One-pot Synthesis of Novel Oximes as Potential Cytotoxic Agents

Author(s): Koduru Sri Shanthi Praveena, Edupuganti Veera Venkat Shivaji Ramarao, Yedla Poornachandra, Chityal Ganesh Kumar, Nallapati Suresh Babu, Nandula Yadagiri Sreenivasa Murthy and Sarbani Pal

Volume 13 , Issue 3 , 2016

Page: [210 - 219] Pages: 10

DOI: 10.2174/1570180812999150819095308

Price: $65

Abstract

An assembly of quinoline, triazole and oxime ether in a single molecular entity afforded a new template that has been used for the generation of a small library of molecules as potential cytotoxic agents. These molecules were synthesized successfully via a one pot multistep method using the copper(I)-catalyzed [3+2]-azide-alkyne cycloaddition (CuAAC) in water as the key step. All these compounds were synthesized in good to excellent yields and were screened for their inhibitory effects on the growth of four cancer cell lines in vitro. Some of these compounds showed encouraging cytotoxic effects against lung cancer cells and inhibition of PDE4 in vitro.

Keywords: Quinoline, 1, 2, 3-triazole, oxime, cancer, PDE4.

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