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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Levetiracetam might act as an efficacious drug to attenuate cognitive deficits of Alzheimer’s disease

Author(s): Rong Xiao

Volume 16, Issue 5, 2016

Page: [565 - 573] Pages: 9

DOI: 10.2174/1568026615666150813144603

Price: $65

Abstract

Levetiracetam is a homologue of piracetam with an a-ethyl side-chain substitution and it is a Food and Drug Administration (FDA) approved antiepileptic drug. Recently, several studies have found that levetiracetam was able to reduce seizure frequency in epileptic seizures patients without affecting their cognitive functions. In the present review, the effects of levetiracetam on cognitive improvement were summarized in epileptic seizures patients with or without Alzheimer's disease (AD), high-grade glioma (HGG) patients and amnestic mild cognitive impairment (aMCI) patients. In addition, levetiracetam was observed to improve the cognitive deficits in normal aged animals and the transgenic animal models with AD, suggesting that levetiracetam may be a better choice for the prevention or treatment of AD.

Keywords: Alzheimer's disease, Cognition deficits, Epileptic seizures, Levetiracetam.

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