Abstract
Tubercidin represents one of the most widely recognized nucleosides isolated from natural sources. The major structural difference between adenosine and tubercidin is that one of the nitrogen atom is replaced by a C-H group in the heterocyclic base. Tubercidin was first introduced into the clinic over 40 years ago. Since then, there has been a steady interest and this review discusses the various approaches related to the synthesis of tubercidin and its derivatives. The key aspects related to isolation, structure-activity relationships and biological activity are also discussed.
Keywords: Tubercidin, natural product, nucleosides, antibiotic, synthesis.
Current Organic Chemistry
Title:Tubercidin and Related Analogues: An Inspiration for 50 years in Drug Discovery
Volume: 20 Issue: 8
Author(s): Varughese A. Mulamoottil
Affiliation:
Keywords: Tubercidin, natural product, nucleosides, antibiotic, synthesis.
Abstract: Tubercidin represents one of the most widely recognized nucleosides isolated from natural sources. The major structural difference between adenosine and tubercidin is that one of the nitrogen atom is replaced by a C-H group in the heterocyclic base. Tubercidin was first introduced into the clinic over 40 years ago. Since then, there has been a steady interest and this review discusses the various approaches related to the synthesis of tubercidin and its derivatives. The key aspects related to isolation, structure-activity relationships and biological activity are also discussed.
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Cite this article as:
A. Mulamoottil Varughese, Tubercidin and Related Analogues: An Inspiration for 50 years in Drug Discovery, Current Organic Chemistry 2016; 20 (8) . https://dx.doi.org/10.2174/1385272819666150803231652
DOI https://dx.doi.org/10.2174/1385272819666150803231652 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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