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Current Neuropharmacology



ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

The Role of Topiramate in the Management of Cocaine Addiction: a Possible Therapeutic Option

Author(s): Antonio Siniscalchi, Antonello Bonci, Nicola Biagio Mercuri, Domenico Pirritano, Aida Squillace, Giovambattista De Sarro and Luca Gallelli

Volume 13 , Issue 6 , 2015

Page: [815 - 818] Pages: 4

DOI: 10.2174/1570159X13666150729222643

Price: $65


Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors).

Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine reinforcement. Therefore, TPM could be used in the management of cocaine dependence.

Keywords: Cocaine dependence, gamma-aminobutyric acid neurotransmission, glutamatergic neurotransmission, topiramate.

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