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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Immunogenicity, Immunopathogenicity, and Immunotolerance in One Graph

Author(s): Darja Kanduc

Volume 15 , Issue 10 , 2015

Page: [1264 - 1268] Pages: 5

DOI: 10.2174/1871520615666150716105543

Price: $65


The concept according to which unique, rare and common sequences may define immunogenicity, immunopathogenicity and immunotolerance, respectively, is graphically illustrated using a melanoma-associatedantigen, Melan-A/Mart-1, as a model. The final picture is consolidated by experimentally validated data from the scientific literature and may represent a concrete prelude to effective immunotherapies exempt from collateral autoimmune reactions.

Keywords: Anti-cancer immunotherapy, autoimmunity, melan-A/Mart-1, immunogenicity, immunopathogenicity, immunotolerance, sequence similarity, the low-similarity theory.

Graphical Abstract

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