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Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued)

Editor-in-Chief

ISSN (Print): 1871-5222
ISSN (Online): 1875-6115

Cognition and State Anxiety are Regulated by Thyroid Hormone Signaling

Author(s): Marc Fisher and Nandini Vasudevan

Volume 15, Issue 1, 2015

Page: [60 - 70] Pages: 11

DOI: 10.2174/187152221501150710130829

Price: $65

Abstract

Anxiety and cognition are both linked to deficits in thyroid hormone concentrations in humans and in rodent models. Both processes have also been shown to be affected by the loss of the thyroid hormone receptors (TR) or by mutant transgenic TRs. Specifically, the unbalanced action of the unliganded TRα1 is thought to be important in the memory deficit and extreme anxiety seen in transgenic mice. The contribution of TRβ is less well defined and the molecular mechanisms that underlie these deficits are also unknown. We review the literature that demonstrates the importance of the thyroid hormone (TH) and the TR in these processes and focus on the mechanisms, in particular adult hippocampal neurogenesis in the dentate gyrus, that might be important in mediating both state anxiety and cognition by thyroid hormone.

Keywords: Thyroid hormone receptors, neurogenesis, spatial memory, BDNF, anxiety.


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