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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

MicroRNAs Used in Combination with Anti-Cancer Treatments Can Enhance Therapy Efficacy

Author(s): Maddalena Mognato and Lucia Celotti

Volume 15, Issue 13, 2015

Page: [1052 - 1062] Pages: 11

DOI: 10.2174/1389557515666150709115355

open access plus


MicroRNAs (miRNAs), a recently discovered class of small non-coding RNAs, constitute a promising approach to anti-cancer treatments when they are used in combination with other agents. MiRNAs are evolutionarily conserved non-coding RNAs that negatively regulate gene expression by binding to the complementary sequence in the 3’-untranslated region (UTR) of target genes. MiRNAs typically suppress gene expression by direct association with target transcripts, thus decreasing the expression levels of target proteins. The delivery to cells of synthetic miRNAs that mimic endogenous miRNA targeting genes involved in the DNA-Damage Response (DDR) can perturb the process, making cells more sensitive to chemotherapy or radiotherapy. This review examines how cells respond to combined therapy and it provides insights into the role of miRNAs in targeting the DDR repair pathway when they are used in combination with chemical compounds or ionizing radiation to enhance cellular sensitivity to treatments.

Keywords: Apoptosis, Cell cycle checkpoints, DNA-Damage Response, DNA Repair, microRNAs, Tumor resistance.

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