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Current Molecular Imaging (Discontinued)

Editor-in-Chief

ISSN (Print): 2211-5552
ISSN (Online): 2211-5544

Glucan Particles Loaded with Fluorinated Emulsions: A Sensitivity Improvement for the Visualization of Phagocytic Cells by 19F-MRI

Author(s): Cristina Chirizzi, Walter Dastrù, Daniela D. Castelli, Valeria Menchise, Silvio Aime and Enzo Terreno

Volume 4 , Issue 1 , 2015

Page: [29 - 34] Pages: 6

DOI: 10.2174/2211555204666150702160805

Price: $65

Abstract

A protocol to load perfluoro-crown-ether (PFCE) nanoemulsion directly into yeast-derived glucan particles (GPs) was developed. It was observed that the PFCE encapsulation did not affect the 19F-MRI properties of the nanoemulsion that is currently in clinical trials. GPs loaded with PFCE nanoemulsion were taken up avidly by murine macrophages in vitro, resulting in a cellular uptake 150 % higher than the not GPs-entrapped nanoemulsion. Accordingly, a corresponding improvement in the 19F-MRI detection of the labelled cells can be obtained. The high biotolerability and versatility of GPs, make these microcarriers a promising option for designing of improved in vivo cellular imaging protocols.

Keywords: 19F-MRI, cellular imaging, glucan particles, macrophages, theranosis, perfluorocarbons.

Graphical Abstract

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