The role of vitamin D towards immune tolerance in white adipose tissue (WAT)

Title:The role of vitamin D towards immune tolerance in white adipose tissue (WAT)

Volume: 15 Issue: 4

Author(s): Salvatore Chirumbolo

Affiliation:

• Department of Medicine-University of Verona, Italy LURM Est Policlinico GB Rossi Piazzale Al Scuro 10 37134 Verona-ITALY.,Italy

Keywords: Calcitriol, leptin, T-reg cells, tolerance, vitamin D, white adipose tissue.

Abstract: Vitamin D and its active form 1α,25(OH)₂D₃ has been recently indicated to have a fundamental role in immune regulation. An interplay between gut and white adipose tissue (WAT), mainly mediated by enterogastric hormones and adipokines, such as leptin, adiponectin and ghrelin, actively participate in the immune homeostasis and modulation both of the innate/acquired immune response and between T-cell effector/T-cell regulatory skewing. Particularly for leptin, this action promotes and enhances immune tolerance at the gut level and pro-inflammatory effect at WAT level, while calcitriol participates in promoting and increasing an M2 macrophage-like skewing, a T-reg activity at WAT level and a iNKT function at gut level. The role of active vitamin D₃ therefore is fundamental in the immune homeostasis of the WAT immune microenvironment and to support the role of WAT as an endocrine, tolerogenic organ.

Cite this article as:

Chirumbolo Salvatore, The role of vitamin D towards immune tolerance in white adipose tissue (WAT), Endocrine, Metabolic & Immune Disorders - Drug Targets 2015; 15(4) . https://dx.doi.org/10.2174/1871530315666150701113811