Cytotoxic Effects on B Lymphocytes Mediated by Reactive Oxygen Species

Title: Cytotoxic Effects on B Lymphocytes Mediated by Reactive Oxygen Species

Volume: 10 Issue: 8

Author(s): Neus Villamor, Emili Montserrat and Dolors Colomer

Affiliation:

• Hematopathology Unit, Hospital Clínic, Villarroel 170, 08036 - Barcelona (Spain).,Spain

Keywords: ros, b cells, lymphoproliferative disorders, rituximab, 2-methoxyoestradiol, imexon, arsenic trioxide 1, 4- benzodiazepine

Abstract: Reactive oxygen species (ROS) are produced in all mammalian cells as a result of normal cellular metabolism and due to the activation of oxidant-producing enzymes in response to exogenous stimuli. The balance between ROS production and antioxidant defenses determines the degree of oxidative stress. Generation of ROS has been associated with cell signaling, stress responses, cell proliferation, aging and cancer development. The ability of ROS to induce cellular damage and to cause cell death opens the possibility to exploit this property in the treatment of cancer through a free radical-mediated mechanism.

Cite this article as:

Villamor Neus, Montserrat Emili and Colomer Dolors, Cytotoxic Effects on B Lymphocytes Mediated by Reactive Oxygen Species, Current Pharmaceutical Design 2004; 10(8) . https://dx.doi.org/10.2174/1381612043452848