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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

A Novel Triazole Nucleoside Suppresses Prostate Cancer Cell Growth by Inhibiting Heat Shock Factor 1 and Androgen Receptor

Author(s): Yi Xia, Menghua Wang, Eliana Beraldi, Mei Cong, Amina Zoubeidi, Martin Gleave and Ling Peng

Volume 15 , Issue 10 , 2015

Page: [1333 - 1340] Pages: 8

DOI: 10.2174/1871520615666150617110943

Price: $65


A novel triazole nucleoside analogue was discovered to exhibit potent anticancer activity in prostate cancer cells via down-regulating heat shock factor 1 (HSF1) and related heat shock proteins, along with the consequential inhibition of androgen receptor (AR) expression and transactivation, arresting the cell cycle in AR-governed phase. This triazole nucleoside therefore constitutes a novel structural paradigm and potential drug candidate for prostate cancer through inhibition of HSF1 and AR.

Keywords: Androgen receptor, anticancer activity, heat shock proteins, heat shock factor 1, nucleoside analogues, prostate cancer.

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