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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Assembling of Supramolecular Capsules with Resorcin[4]arene and Calix[n]arene Building Blocks

Author(s): Chiara M. A. Gangemi, Andrea Pappalardo and Giuseppe Trusso Sfrazzetto

Volume 19, Issue 23, 2015

Page: [2281 - 2308] Pages: 28

DOI: 10.2174/1385272819666150608221916

Price: $65


Molecular capsules are containers endowed with isolated nanometer-sized cavities. In particular, supramolecular capsules generated by exploiting hydrogen bonds, metal-coordination bonds and/or hydrophobic effects represent an intriguing version of these fascinating molecules, and an impressive challenge for synthetic chemists. Resorcin[4]arene-based cavitands and conformationally preorganized calixarenes are two classes of receptors largely used as building blocks for the construction of these assemblies. This review focuses on the capsular self-assembly of suitably functionalized building blocks, analyzing from time to time the main driving force(s) involved for their formation.

Keywords: Calix[n]arenes, hydrogen bond, metal-coordination, molecular recognition, resorcin[4]arene, self-assembly, supramolecular capsules.

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