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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Revision of the Synthesis and Pharmacological Activity of a Reported Translation Inhibitor

Author(s): Christine Basmadjian, Helene Malka-Mahieu and Laurent Desaubry

Volume 15 , Issue 10 , 2015

Page: [1305 - 1307] Pages: 3

DOI: 10.2174/1871520615666150602092450

Price: $65


4EGI-1 is the prototype of a novel class of anticancer agents targeting translation. Patented drug-like analogue 1 was synthesized and examined for inhibition of translation and cytotoxicity in cancer cells. Unexpectedly, 1 was found inactive in both assays.

Keywords: Cancer, eIF4E, metastatic melanoma, mRNA translation, protein synthesis, thiazoles.

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