Abstract
DNA enzymes, or DNAzymes, are all-DNA molecules with inherent catalytic activity that bind and cleave at their complementary sequence in the target mRNA through Watson-Crick base pairing. These agents have been successfully used to tease out the role the targeted gene plays in both cellular systems and in a variety of animal models. DNAzymes have the potential to serve as novel nucleic acid-based therapeutic agents in pathologies involving aberrant smooth muscle cell growth and a range of other disorders.
Keywords: dnazymes, post-angioplasty restenosis, egr-1
Current Pharmaceutical Biotechnology
Title: Deoxyribozymes as Inhibitors of Vascular Smooth Muscle Cell Growth
Volume: 5 Issue: 4
Author(s): Levon M. Khachigian
Affiliation:
Keywords: dnazymes, post-angioplasty restenosis, egr-1
Abstract: DNA enzymes, or DNAzymes, are all-DNA molecules with inherent catalytic activity that bind and cleave at their complementary sequence in the target mRNA through Watson-Crick base pairing. These agents have been successfully used to tease out the role the targeted gene plays in both cellular systems and in a variety of animal models. DNAzymes have the potential to serve as novel nucleic acid-based therapeutic agents in pathologies involving aberrant smooth muscle cell growth and a range of other disorders.
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Cite this article as:
Khachigian M. Levon, Deoxyribozymes as Inhibitors of Vascular Smooth Muscle Cell Growth, Current Pharmaceutical Biotechnology 2004; 5 (4) . https://dx.doi.org/10.2174/1389201043376788
DOI https://dx.doi.org/10.2174/1389201043376788 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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