摘要
耐药性是最严重的公共健康问题之一,尤其当细菌同时耐受多种抗菌药和形成生物膜时。结果,治疗感染的手段将会受到限制,频繁地引起感染复发,治疗失败及发病率和死亡率的增长。同时,耐药性的持续和传播,加之现代抗生素效力的下降和毒性的上升对寻找抗菌物质替代资源提出了迫切需要。植物被认为是一种未开发的具有高效治疗潜力的化学结构资源,其功能包括抵抗临床重要微生物的抗菌活性。此外,与合成化合物相比,植物来源的化学物质(植物次生代谢产物)具有多种优势,包括绿色来源和抵御耐药性的多种抗菌机制。在本次研究中,我们概述了具有抗菌性能的主要几类植物化学成分和它们的作用模式。植物化学成分应用于生物膜的预防和控制方面也做了补充。此外,植物化学成分作为新型功能分子的支架,扩展了抗菌途径。
关键词: 耐药性,生物膜控制,传染性生物膜,作用模式,天然产物,植物化学成分
Current Medicinal Chemistry
Title:Insights on Antimicrobial Resistance, Biofilms and the Use of Phytochemicals as New Antimicrobial Agents
Volume: 22 Issue: 21
Author(s): Anabela Borges, Maria J. Saavedra and Manuel Simoes
Affiliation:
关键词: 耐药性,生物膜控制,传染性生物膜,作用模式,天然产物,植物化学成分
摘要: Antimicrobial resistance is one of the most serious public health problems. This is of particular concern when bacteria become resistant to various antimicrobial agents simultaneously and when they form biofilms. Consequently, therapeutic options for the treatment of infections have become limited, leading frequently to recurrent infections, treatment failure and increase of morbidity and mortality. Both, persistence and spread of antibiotic resistance, in combination with decreased effectiveness and increased toxicity of current antibiotics have emphasized the urgent need to search alternative sources of antimicrobial substances. Plants are recognized as a source of unexplored chemical structures with high therapeutic potential, including antimicrobial activity against clinically important microorganisms. Additionally, phytochemicals (plant secondary metabolites) present several advantages over synthetic molecules, including green status and different mechanisms of action from antibiotics which could help to overcome the resistance problem. In this study, an overview of the main classes of phytochemicals with antimicrobial properties and their mode of action is presented. A revision about the application of phytochemicals for biofilm prevention and control is also done. Moreover, the use of phytochemicals as scaffolds of new functional molecules to expand the antibiotics pipeline is reviewed.
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Anabela Borges, Maria J. Saavedra and Manuel Simoes , Insights on Antimicrobial Resistance, Biofilms and the Use of Phytochemicals as New Antimicrobial Agents, Current Medicinal Chemistry 2015; 22 (21) . https://dx.doi.org/10.2174/0929867322666150530210522
DOI https://dx.doi.org/10.2174/0929867322666150530210522 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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