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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Targeting Protein-Protein Interactions in the Proteasome Super-Assemblies.

Author(s): Maria Gaczynska and Pawel A. Osmulski

Volume 15 , Issue 20 , 2015

Page: [2056 - 2067] Pages: 12

DOI: 10.2174/1568026615666150519103206

Price: $65

Abstract

Protein-protein interactions (PPI) are at the center of molecular mechanisms of life. The protein ligands convene for regulation of biological function: adding, enhancing or inhibiting activity, for assistance in structural integrity or to enable subsequent PPI. All these general roles of PPI are represented in the proteasome, the giant proteolytic factory universally present in human cells. The proteasome is a renowned target for anti-cancer drugs and a considered target for drugs curbing inflammation. The essential function of the proteasome, the degradation of a majority of intracellular proteins via the ubiquitin-proteasome pathway, relies on proper interactions between multiple subunits of the enzyme and between multiple modules forming distinct super-assemblies covered by the “proteasome” name. The interface regions between constitutive, alternative or transient protein components of the proteasome provide a rich platform for design of drugs with potentially very diverse actions. Still, the resource remains largely untapped since all proteasometargeting drugs used so far in humans are classical competitive inhibitors blocking catalytic centers. In this review, we will discuss the opportunities and challenges of targeting PPI in the hub enzyme for intracellular protein catabolism, the proteasome.

Keywords: Allostery, Cancer, Drugs, Inhibitors, Proteasome, Protein-protein interactions, Proteolysis, Ubiquitin-proteasome pathway.

Graphical Abstract

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