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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Oligonucleotides and Oligonucleotide Conjugates: A New Approach for Cancer Treatment

Author(s): Tatiana Da Ros, Giampiero Spalluto, Maurizio Prato, Tula Saison-Behmoaras, Alexandre Boutorine and Barbara Cacciari

Volume 12 , Issue 1 , 2005

Page: [71 - 88] Pages: 18

DOI: 10.2174/0929867053363603

Price: $65


In this account we summarise recent studies on oligonucleotides and oligonucleotide derivatives and their utilisation in antigene, antisense and decoy approaches, with particular attention to peptide nucleic acids, locked nucleic acids and oligonucleotide conjugates, the most promising compounds in this field.

Keywords: antisense oligonucleotides, mrna, Rnase, hybridisation, gene-directed therapy

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