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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design

Author(s): Lidia Moreira Lima and Eliezer J. Barreiro

Volume 12, Issue 1, 2005

Page: [23 - 49] Pages: 27

DOI: 10.2174/0929867053363540

Price: $65

Abstract

This review aim to demonstrate the role of bioisosterism in rational drug design as well as in the molecular modification and optimization process aiming to improve pharmacodynamic and pharmacokinetic properties of lead compounds.

Keywords: lead compound, isosterism, antagonist, pharmacodynamic, pharmacokinetic, hplc, prostaglandin-h synthase-2 (pghs-

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