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Current Alzheimer Research


ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

A Novel Tetradentate Ruthenium(II) Complex Containing Tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation

Author(s): Sharon Lai-Fung Chan, Lihua Lu, Tsz Lung Lam, Siu-Cheong Yan, Chung-Hang Leung and Dik-Lung Ma

Volume 12 , Issue 5 , 2015

Page: [434 - 438] Pages: 5

DOI: 10.2174/1567205012666150504150726

Price: $65


We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO4 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.

Keywords: 2-acetylbenzo[b]thiophen-3-olate, Alzheimer's disease, beta-amyloid, ruthenium(II), tris(2-pyridylmethyl)amine.

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