Generic placeholder image

Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Protein Tyrosine Phosphatases and their Inhibitors

Author(s): Purushottam M. Dewang, Nai-Mu Hsu, Shao-Zheng Peng and Wen-Ren Li

Volume 12 , Issue 1 , 2005

Page: [1 - 22] Pages: 22

DOI: 10.2174/0929867053363504

Price: $65

Abstract

Protein tyrosine phosphatase (PTP) is the family of enzymes that are key players in cellular signal transduction system and perturbation in their functioning is implicated in many disease-states. Diverse chemical compounds are being synthesized and evaluated as PTP inhibitors. This review presents a brief account of various enzymes of the PTP family and their inhibitors. Peculiar features of these enzymes and their roles in various diseases are summarized along with important inhibitors developed in recent years.

Keywords: cellular signaling, diseases, ptps, sar, inhibitors, therapeutics/drugs


Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy