Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Overcoming the Skin Permeation Barrier: Challenges and Opportunities

Author(s): Carla Vitorino, Joao Sousa and Alberto Pais

Volume 21, Issue 20, 2015

Page: [2698 - 2712] Pages: 15

DOI: 10.2174/1381612821666150428124053

Price: $65

Abstract

Stratum corneum (SC), the outermost layer of the skin, constitutes an excellent protective physiological barrier, and is the main challenge in transdermal drug delivery. Many approaches have been used to enhance the penetration of drugs through this layer, covering passive and active methods or the combination of both. This opens the opportunity to broaden the spectrum of drugs that can be administered through the skin, providing alternatives to existing products, and filling gaps that conventional routes failed to occupy. In this review, an overview of the different permeation enhancing methodologies is carried out, focusing on the combination of lipid nanoparticles with conventional chemical enhancers, as a proof-of-concept of a successful development strategy.

Keywords: Active methods, chemical penetration enhancers, lipid nanoparticles, microneedles, passive methods, permeation enhancement, transdermal delivery.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy