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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

NADPH Oxidases and Inflammatory Bowel Disease

Author(s): Giang Lam, Vasso Apostolopoulos, Anthony Zulli and Kulmira Nurgali

Volume 22 , Issue 17 , 2015

Page: [2100 - 2109] Pages: 10

DOI: 10.2174/0929867322666150416095114

Price: $65

Abstract

The nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase, NOX) enzyme family catalyzes the production of reactive oxygen species (ROS). ROS have functional roles in cell cycling and signal transduction but their excessive production results in oxidative stress which is believed to have pathological consequences. Oxidative stress in the intestinal tract is considered a major factor contributing to the pathogenesis and progression of inflammatory bowel disease (IBD), as recent data suggest a positive correlation between upregulated NOX and gastrointestinal inflammation. Moreover, expression of certain NOX gene variants has been shown to affect the susceptibility of an individual to develop IBD. As current treatments for IBD are not entirely effective, the pharmacological inhibition of NOX is an unexplored avenue that could provide a potential therapeutic target for the treatment of this disease.

Keywords: Inflammatory bowel disease (IBD), nicotinamide adenine dinucleotide phosphate oxidase (NADPH), nitric oxide (NO), reactive oxygen species (ROS).


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