Abstract
In recent years, severe infections caused by the Gram positive pathogen Staphylococcus aureus have emerged both in community and clinical settings. The increased infection rates are explained by the versatility and resistance of this pathogen, which produces a wide arsenal of virulence factors, organize within difficult to eradicate biofilms and displays various resistance genes, leading current antibiotic therapies ineffective. Nanotechnological progress highlights the impact of magnetic nanoparticles in the current and future diagnosis and therapy procedures of the infectious diseases. These nanostructures could be used as efficient carriers for many natural and synthetic antimicrobials, which may be further utilized for the development of soluble anti-Staphylococcal formulations and improved surfaces and coatings of different uses, optimized to reduce attachment and biofilm formation.
Keywords: Biofilms, Magnetic nanoparticles, Novel antimicrobials, Resistant pathogens, Staphylococcus aureus, Virulence.
Graphical Abstract
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
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Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
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Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
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