Abstract
Peptide aptamers are small combinatorial proteins that are selected to bind to specific sites on their target molecules. Peptide aptamers consist of short, 5-20 amino acid residues long sequences, typically embedded as a loop within a stable protein scaffold. Various peptide aptamer scaffolds and in vitro and in vivo selection techniques are reviewed with emphasis on specific biomedical, bioimaging, and bioanalytical applications.
Keywords: Affibodies, Affilins, Anticalins, Armadillo repeat, Atrimers, Avimers, Cell display, Combinatorial libraries, Darpins, Directed evolution, DNA display, Fynomers, Knottins, Kunitz domain, Monobodies, mRNA display, OBodies, Phage display, Peptide aptamers, Protein scaffold, Ribosome display, Thioredoxin, Yeast two hybrid.
Current Topics in Medicinal Chemistry
Title:Peptide Aptamers: Development and Applications
Volume: 15 Issue: 12
Author(s): Sergey Reverdatto, David S. Burz and Alexander Shekhtman
Affiliation:
Keywords: Affibodies, Affilins, Anticalins, Armadillo repeat, Atrimers, Avimers, Cell display, Combinatorial libraries, Darpins, Directed evolution, DNA display, Fynomers, Knottins, Kunitz domain, Monobodies, mRNA display, OBodies, Phage display, Peptide aptamers, Protein scaffold, Ribosome display, Thioredoxin, Yeast two hybrid.
Abstract: Peptide aptamers are small combinatorial proteins that are selected to bind to specific sites on their target molecules. Peptide aptamers consist of short, 5-20 amino acid residues long sequences, typically embedded as a loop within a stable protein scaffold. Various peptide aptamer scaffolds and in vitro and in vivo selection techniques are reviewed with emphasis on specific biomedical, bioimaging, and bioanalytical applications.
Export Options
About this article
Cite this article as:
Reverdatto Sergey, Burz S. David and Shekhtman Alexander, Peptide Aptamers: Development and Applications, Current Topics in Medicinal Chemistry 2015; 15 (12) . https://dx.doi.org/10.2174/1568026615666150413153143
DOI https://dx.doi.org/10.2174/1568026615666150413153143 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Outlook on Epigenetic Therapeutic Approaches for Treatment of Gastric Cancer
Current Cancer Drug Targets EDITORIAL (Thematic Issue: Special Thematic Issuue: Development of Biomarkers in Tumors of Digestive System Part I)
Anti-Cancer Agents in Medicinal Chemistry New and Highly Potent Antitumor Natural Products from Marine-Derived Fungi: Covering the Period from 2003 to 2012
Current Topics in Medicinal Chemistry Pharmacokinetic Concepts Revisited - Basic and Applied
Current Pharmaceutical Biotechnology Triterpenoids for Cancer Prevention and Treatment: Current Status and Future Prospects
Current Pharmaceutical Biotechnology Delivery of Intracellular-Acting Biologics in Pro-Apoptotic Therapies
Current Pharmaceutical Design Patent Annotations
Recent Patents on CNS Drug Discovery (Discontinued) Frontier Lipid-Based Carrier Systems for Drug Targeting: A Laconic Review on Niosomes
Pharmaceutical Nanotechnology Sympathetic Signaling in Angiogenesis: Implications for Cancer Progression
Current Cancer Therapy Reviews Verbascoside Attenuates Rac-1 and HIF-1α Signaling Cascade in Colorectal Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry Small Interfering RNA for Effective Cancer Therapies
Mini-Reviews in Medicinal Chemistry Curcuminoid Metabolism and its Contribution to the Pharmacological Effects
Current Drug Metabolism ErbB4 and its Isoforms: Patentable Drug Targets?
Recent Patents on DNA & Gene Sequences Endoscopic Ultrasonography: A Novel Management Strategy for Pancreatic Diseases
Current Signal Transduction Therapy Cdc42 Signaling Pathway Inhibition as a Therapeutic Target in Ras- Related Cancers
Current Medicinal Chemistry Mast Cells as Target in Cancer Therapy
Current Pharmaceutical Design Active-Targeted Nanotherapy Strategies for Prostate Cancer
Current Cancer Drug Targets Non-coding RNAs in Exosomes: New Players in Cancer Biology
Current Genomics Pathophysiology of Diabetic Dyslipidaemia
Current Vascular Pharmacology Recent Patents on Proteasome Inhibitors of Natural Origin
Recent Patents on Anti-Cancer Drug Discovery