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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Identification and Synthesis of Major Impurities Formed During the Synthesis of Trifloxystrobin and Kresoxim-methyl Fungicides

Author(s): Pasumpon Kamaraj, Nakita Antao, Apoorva Singh, Vijay Satam, Subhash Kadam, Venkatesh M. Prabhu, Rama Mohan Hindupur and Hari N. Pati

Volume 12, Issue 5, 2015

Page: [306 - 310] Pages: 5

DOI: 10.2174/1570178612666150318002831

Price: $65


During process development of Trifloxystrobin and Kresoxim-methyl fungicides, two impurities were identified. These impurities were isolated and characterized using LCMS, IR, 1H NMR, 13C NMR and elemental analysis. Structures of the impurities were further unambiguously confirmed by their independent synthesis. Structure of both impurities revealed that they possess methyl (E)-methoxyiminoacetate pharmacophore, responsible for antifungal activities of strobilurins, in combination with arylmethyl (E)-methoxyiminoacetate framework.

Keywords: Fungicide, impurities, Kresoxim-methyl, pharmacophore, strobilurins, Trifloxystrobin.

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