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Current HIV Research

Editor-in-Chief

ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Meta-Analysis and Time Series Modeling Allow a Systematic Review of Primary HIV-1 Drug-Resistant Prevalence in Latin America and Caribbean

Author(s): Antonio Victor Campos Coelho, Ronald Rodrigues De Moura, Ronaldo Celerino Da Silva, Anselmo Jiro Kamada, Rafael Lima Guimaraes, Lucas Andre Cavalcanti Brandao, Hemílio Fernandes Campos Coelho and Sergio Crovella

Volume 13 , Issue 2 , 2015

Page: [125 - 142] Pages: 18

DOI: 10.2174/1570162X13999150317155040

Price: $65

Abstract

Here we review the prevalence of HIV-1 primary drug resistance in Latin America and Caribbean using meta-analysis as well as time-series modeling. We also discuss whether there could be a drawback to HIV/AIDS programs due to drug resistance in Latin America and Caribbean in the next years. We observed that, although some studies report low or moderate primary drug resistance prevalence in Caribbean countries, this evidence needs to be updated. In other countries, such as Brazil and Argentina, the prevalence of drug resistance appears to be rising. Mutations conferring resistance against reverse transcriptase inhibitors were the most frequent in the analyzed populations (70% of all mutational events). HIV-1 subtype B was the most prevalent in Latin America and the Caribbean, although subtype C and B/F recombinants have significant contributions in Argentina and Brazil. Thus, we suggest that primary drug resistance in Latin America and the Caribbean could have been underestimated. Clinical monitoring should be improved to offer better therapy, reducing the risk for HIV-1 resistance emergence and spread, principally in vulnerable populations, such as men who have sex with men transmission group, sex workers and intravenous drug users.

Keywords: Drug resistance mutation, HAART, primary drug resistance, meta-analysis, systematic review, time series.

Graphical Abstract

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