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Endocrine, Metabolic & Immune Disorders - Drug Targets


ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Adiponectin as a Target in Obesity-related Inflammatory State

Author(s): Koji Ohashi, Daisuke Yuasa, Rei Shibata, Toyoaki Murohara and Noriyuki Ouchi

Volume 15, Issue 2, 2015

Page: [145 - 150] Pages: 6

DOI: 10.2174/1871530315666150316122709

Price: $65


Accumulating evidence indicates that low grade inflammation is closely associated with obesity-related disorders including type 2 diabetes, hypertension and atherosclerosis. Adiponectin is a fat-derived plasma protein with anti-inflammatory functions. Circulating levels of adiponectin are decreased in obese states, and these conditions are broadly associated with various obesity-related diseases. Furthermore, adiponectin has direct protective functions against cardiovascular disease, cerebrovascular disease, non-alcoholic steatohepatitis (NASH) and chronic kidney disease (CKD). In this review, we will focus on the protective functions of adiponectin against these obesity-related diseases from the view point of its anti-inflammatory properties.

Keywords: Adiponectin, cardiovascular disease, cerebrovascular disease, CKD, inflammation, insulin resistance, NASH.

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