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Current Radiopharmaceuticals

Editor-in-Chief

ISSN (Print): 1874-4710
ISSN (Online): 1874-4729

Theranostic Radiopharmaceuticals Based on Gold Nanoparticles Labeled with 177Lu and Conjugated to Peptides

Author(s): Guillermina Ferro-Flores, Blanca E. Ocampo-García, Clara L. Santos-Cuevas, Flor de María Ramírez, Erika P. Azorín-Vega and Laura Meléndez-Alafort

Volume 8, Issue 2, 2015

Page: [150 - 159] Pages: 10

DOI: 10.2174/1874471008666150313115423

Price: $65

Abstract

Gold nanoparticles (AuNPs) have been proposed for a variety of medical applications such as localized heat sources for cancer treatment and drug delivery systems. The conjugation of peptides to AuNPs produces stable multimeric systems with target-specific molecular recognition. Lutetium- 177 (177Lu) has been successfully used in peptide radionuclide therapy. Recently, 177Lu-AuNPs conjugated to different peptides have been proposed as a new class of theranostic radiopharmaceuticals. These radioconjugates may function simultaneously as molecular imaging agents, radiotherapy systems and thermal-ablation systems. This article covers advancements in the design, synthesis, physicochemical characterization, molecular recognition assessment and preclinical therapeutic efficacy of gold nanoparticles radiolabeled with 177Lu and conjugated to RGD (-Arg-Gly-Asp-), Lys3-Bombesin and Tat(49-57) peptides.

Keywords: Bombesin, cancer thermotherapy, gold nanoparticles, gold nanoparticles-peptides, lutetium-177, RGD, targeted radiotherapy, Tat-peptides.

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