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Medicinal Chemistry


ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Recognition and Impact of Host-derived Molecules on Bacterial Cell-tocell Signalling Pathways

Author(s): Alina-Maria Holban, Mariana Carmen Chifiriuc and Veronica Lazar

Volume 11 , Issue 7 , 2015

Page: [610 - 617] Pages: 8

DOI: 10.2174/1573406411666150305113146

Price: $65


Microbe-host signalling is now a well accepted concept and an intensively studied research field. Although some of the observed bacterial phenotypes are atributed to host-recognition and interkingdom signalling, most of them are not relying on a proved molecular mechanism. Recent progress revealed some recognition and signalling pathways for host molecules in bacterial cells, which try to explain their modulatory effect on growth and virulence. Since the current knowledge on the field is poor and debatable, the purpose of this paper is to review and discuss the research performed in order to elucidate the ways by which microbial cells recognize and decode the host molecule signals.

Keywords: Inter-kingdom signalling, stress hormones, catecholamines, pathogens, virulence, growth.

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