摘要
孤独症谱系障碍(ASD)和精神分裂症(SCZ)是具有复杂的遗传结构的认知障碍与行为表型的重叠,这表明其具有共同通路扰动。许多证据显示兴奋和抑制性活动的失衡(E/I失衡)是其一个共同的病理生理机制。因此,了解E/I失衡的分子基础,可能提供对这些疾病的病的基本了解和可能发现未来药物开发的新靶点。在这里,我们综述关键的基因、生理、神经病理、功能、和通路的研究,表明兴奋/抑制环路的改变是ASD和SCZ发病机制的关键。
关键词:
Current Molecular Medicine
Title:Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders
Volume: 15 Issue: 2
Author(s): R. Gao and P. Penzes
Affiliation:
关键词:
摘要: Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with complex genetic architectures but overlapping behavioral phenotypes, which suggests common pathway perturbations. Multiple lines of evidence implicate imbalances in excitatory and inhibitory activity (E/I imbalance) as a shared pathophysiological mechanism. Thus, understanding the molecular underpinnings of E/I imbalance may provi de essential insight into the etiology of these disorders and may uncover novel targets for future drug discovery. Here, we review key genetic, physiological, neuropathological, functional, and pathway studies that suggest alterations to excitatory/inhibitory circuits are keys to ASD and SCZ pathogenesis.
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Cite this article as:
R. Gao and P. Penzes , Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders, Current Molecular Medicine 2015; 15 (2) . https://dx.doi.org/10.2174/1566524015666150303003028
DOI https://dx.doi.org/10.2174/1566524015666150303003028 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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