摘要
精神疾病不仅是由遗传因素引起的,而且也是由环境因素等复杂因素引起。此外,环境因素很少像生物学和生化指标一样被量化,这使得了解精神疾病的病理情况以及其潜在的发病机制极其困难。此外,我们实际上已经没有其他的选择,只能对显示出精神病特征的人类进行死后大脑的生物学研究,因而导致缺乏实验材料来描述这些疾病的基本生物学特征。从这样的背景下,可用于基础研究的动物、组织或细胞模型,是了解精神疾病生物学上的致病机制是不可缺少的。在这篇综述中,我们讨论了精神障碍的微内表型的重要性,即:精神疾病在分子动力学、突触、神经元、神经环路水平上的表型,作为对这些疾病的基础研究的目标。
关键词: 动物模型,抑郁狂躁型忧郁症,抑郁症,内表型,微内表型,精神障碍,创伤后精神紧张性精神障碍,精神分裂症
Current Molecular Medicine
Title:Microendophenotypes of Psychiatric Disorders: Phenotypes of Psychiatric Disorders at the Level of Molecular Dynamics, Synapses, Neurons, and Neural Circuits
Volume: 15 Issue: 2
Author(s): S. Kida and T. Kato
Affiliation:
关键词: 动物模型,抑郁狂躁型忧郁症,抑郁症,内表型,微内表型,精神障碍,创伤后精神紧张性精神障碍,精神分裂症
摘要: Psychiatric disorders are caused not only by genetic factors but also by complicated factors such as environmental ones. Moreover, environmental factors are rarely quantitated as biological and biochemical indicators, making it extremely difficult to understand the pathological conditions of psychiatric disorders as well as their underlying pathogenic mechanisms. Additionally, we have actually no other option but to perform biological studies on postmortem human brains that display features of psychiatric disorders, thereby resulting in a lack of experimental materials to characterize the basic biology of these disorders. From these backgrounds, animal, tissue, or cell models that can be used in basic research are indispensable to understand biologically the pathogenic mechanisms of psychiatric disorders. In this review, we discuss the importance of microendophenotypes of psychiatric disorders, i.e., phenotypes at the level of molecular dynamics, neurons, synapses, and neural circuits, as targets of basic research on these disorders.
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Cite this article as:
S. Kida and T. Kato , Microendophenotypes of Psychiatric Disorders: Phenotypes of Psychiatric Disorders at the Level of Molecular Dynamics, Synapses, Neurons, and Neural Circuits, Current Molecular Medicine 2015; 15 (2) . https://dx.doi.org/10.2174/1566524015666150303002128
DOI https://dx.doi.org/10.2174/1566524015666150303002128 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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