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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Necrosis Avidity of Organic Compounds: A Natural Phenomenon with Exploitable Theragnostic Potentials

Author(s): Marlein Miranda Cona, Raymond Oyen and Yicheng Ni

Volume 22, Issue 15, 2015

Page: [1829 - 1849] Pages: 21

DOI: 10.2174/0929867322666150227153550

Price: $65


Necrosis is an in vivo chaotic event distinguished by uncontrolled disintegration of the cell membrane leading to cytolysis, inflammation and tissue destruction followed by a healing or regenerating process. Targeting necrosis may offer potential diagnostic, therapeutic and/or theragnostic applications in translational medicine. This article reviews the current concept of necrosis including definition, etiology and pathophysiology. The evolution and development of a wide diversity of necrosis targeting agents and their potential applications in preclinical and clinical settings are also elaborated and discussed.

Keywords: Cancer, cardiovascular diseases, diagnosis, necrosis, necrosis avid compounds, treatment.

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