摘要
皮肤衰老是人类生命的不可避免的生理现象。年龄增长给外皮系统的所有部分带来皮肤上随之而来的迹象。皮肤衰老主要是由于内在(按时间顺序的)和外在衰老(光老化)。光老化是暴露于紫外线辐射的结果。尽管经济条件多变,基于天然产物的护肤市场继续见长。在此背景下,天然抗衰老药物的研究极大扩展,近年来大量植物产品被研究。本文集中强调依据科源分类和提供的抗衰老天然产品当前认识的最新进展。35个科的植物被综述。多种植物分子,尤其来源于多酚、三萜和甾体类,展示了具有前景的活性。其中,鼠尾草酸、仙茅苷、姜黄素、甘草酸、芒果苷、mirkoin、积雪草苷、迷迭香酸、鸢尾苷、酪醇等,能够抑制酪氨酸酶、透明质酸酶、弹性蛋白酶、胶原酶,从皮肤细胞清除自由基,防止经皮失水,有助于防止皮肤皱纹,被大量研究并在本文中被讨论。来自豆科、Asperaceae和姜科的提取物和纯化合物被尤其关注,并且似乎在抗衰老产品的开发中最有前景。
关键词: 天然化合物,光老化,植物提取物,皮肤衰老,皱纹。
Current Medicinal Chemistry
Title:Potential Role of Natural Compounds Against Skin Aging
Volume: 22 Issue: 12
Author(s): R. Tundis, M.R. Loizzo, M. Bonesi and F. Menichini
Affiliation:
关键词: 天然化合物,光老化,植物提取物,皮肤衰老,皱纹。
摘要: Skin aging is an inevitable biological phenomenon of human life. Advancing age brings changes to all components of the integumentary system with consequent signs on the skin. Skin aging is mainly due to intrinsic (chronologic) and extrinsic aging (photo-aging). Photo-aging is a consequence of exposure to ultraviolet radiations. Despite variable economic conditions, the skin care market based on natural products continues to see strong growth. In this context, the research of naturally occurring anti-aging agents is greatly expanding and in recent years numerous plant-derived products have been investigated. This review article focuses on highlighting recent advances in current knowledge on anti-aging natural products grouped and presented according to their family origin. Plants from 35 families were reviewed. A variety of phytomolecules, derived in particular from polyphenols, triterpenes and sterols classes, demonstrated a promising activity. Among them carnosic acid, curculigoside, curcumin, glycyrrhizic acid, mangiferin, mirkoin, asiaticoside, rosmarinic acid, tectorigenin, tyrosol etc., able to inhibit tyrosinase, hyaluronidase, elastase, and collagenase, to scavenge free radicals from skin cells, to prevent trans-epidermal water loss, and to contribute to protect skin from wrinkles, were largely investigated and herein discussed. Extracts and pure compounds from Fabaceae, Asperaceae and Zingiberaceae families have shown particular interest and appear most promising in the development of anti-aging products.
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R. Tundis, M.R. Loizzo, M. Bonesi and F. Menichini , Potential Role of Natural Compounds Against Skin Aging, Current Medicinal Chemistry 2015; 22 (12) . https://dx.doi.org/10.2174/0929867322666150227151809
DOI https://dx.doi.org/10.2174/0929867322666150227151809 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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