摘要
由于大脑血管阻塞引起的脑缺血,会引起缺血性组织死亡;而且近期研究表明中风后炎症很大程度上会加快缺血的病理性发展。因为与初次损伤的救援相比,紧随动脉闭塞大脑炎症引起的二次损伤也许有一个更长的治疗时间窗,炎症控制将是比较明显的治疗靶点。近几年,报道了大量的该领域的实验研究进展。然而,炎症是一复杂系列的炎症细胞和分子之间相互作用,其中可能是有害的或者有益的,所以对缺血性脑中风炎症反应的精确机制进行阐述是困难的。我们综述了脑缺血方面的神经炎症和炎症信号通路调节方面的研究进展。也包括了治疗缺血性中风的潜在靶点。免疫系统和与修复相对的脑损伤的作用将会有助于阐明免疫调节是怎么又可能治疗中风的。
关键词: 脑缺血,炎症,神经保护,中风
Current Medicinal Chemistry
Title:Inflammatory Responses in Brain Ischemia
Volume: 22 Issue: 10
Author(s): Masahito Kawabori and Midori A. Yenari
Affiliation:
关键词: 脑缺血,炎症,神经保护,中风
摘要: Brain infarction causes tissue death by ischemia due to occlusion of the cerebral vessels and recent work has shown that post stroke inflammation contributes significantly to the development of ischemic pathology. Because secondary damage by brain inflammation may have a longer therapeutic time window compared to the rescue of primary damage following arterial occlusion, controlling inflammation would be an obvious therapeutic target. A substantial amount of experimentall progress in this area has been made in recent years. However, it is difficult to elucidate the precise mechanisms of the inflammatory responses following ischemic stroke because inflammation is a complex series of interactions between inflammatory cells and molecules, all of which could be either detrimental or beneficial. We review recent advances in neuroinflammation and the modulation of inflammatory signaling pathways in brain ischemia. Potential targets for treatment of ischemic stroke will also be covered. The roles of the immune system and brain damage versus repair will help to clarify how immune modulation may treat stroke.
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Cite this article as:
Masahito Kawabori and Midori A. Yenari , Inflammatory Responses in Brain Ischemia, Current Medicinal Chemistry 2015; 22 (10) . https://dx.doi.org/10.2174/0929867322666150209154036
DOI https://dx.doi.org/10.2174/0929867322666150209154036 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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