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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Exit from Mycobacterial Dormancy: A Structural Perspective

Author(s): Flavia Squeglia, Alessia Ruggiero and Rita Berisio

Volume 22, Issue 14, 2015

Page: [1698 - 1709] Pages: 12

DOI: 10.2174/0929867322666150209153027

Price: $65


Dormancy in mycobacteria is defined as a stable but reversible non-replicating state in response to stresses. In Mycobacterium tuberculosis, an important human pathogen, this state is responsible for latent Tuberculosis. The current chemotherapy to defeat Tuberculosis while effective in killing growing tubercle bacilli is largely ineffective in killing dormant bacilli. For this reason there is a recent interest to develop new drugs against this disease in the latent form. To this aim, the knowledge of the molecular basis of bacterial resuscitation from dormancy is necessary and of paramount importance. This review summarizes the current knowledge on the complex mechanism of exit from mycobacterial dormancy; the main molecular players responsible for mycobacterial resuscitation from dormancy are described and their role is discussed from a structural perspective.

Keywords: Dormancy, mycobacteria, resuscitation, structure.

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