Liposomes as siRNA Delivery Vectors

Title:Liposomes as siRNA Delivery Vectors

Volume: 15 Issue: 9

Author(s): Sabrina Bochicchio, Annalisa Dalmoro, Anna Angela Barba, Gabriele Grassi and Gaetano Lamberti

Affiliation:

Keywords: Drug delivery, encapsulating methods, liposomes, nucleic acid based drugs (NABDs), polymeric carriers, small interfering RNAs (siRNAs).

Abstract: Nucleic Acid Based Drugs (NABDs) constitute a class of promising and powerful therapeutic new agents with limited side effects, potentially useable against a wide range of diseases, including cancer. Among them, the short interfering RNAs (siRNAs), represent very effective molecules. Despite their in vitro efficacy, the major drawback that limits siRNAs usage consists in a difficult delivery due to their very low stability in physiological fluids, and to their limited membrane-permeability through physiological barriers. On the other hand, the liposomes (lipid bilayers closed in vesicles of various sizes) represent interesting drug delivery systems (DDSs) which can be tailored in order to get the best performance in terms of load, vesicle size and transfection yield. In this work, the current state of study in these two fields, and the connections between them, are briefly summarized.

Cite this article as:

Bochicchio Sabrina, Dalmoro Annalisa, Barba Angela Anna, Grassi Gabriele and Lamberti Gaetano, Liposomes as siRNA Delivery Vectors, Current Drug Metabolism 2014; 15(9) . https://dx.doi.org/10.2174/1389200216666150206124913