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Current Green Chemistry


ISSN (Print): 2213-3461
ISSN (Online): 2213-347X

Montmorillonite K-10 Clay Mediated Green Synthesis of 2-Amino-4-aryl thiazole Derivatives from α-Brominated Aralkyl Ketones in Water

Author(s): Pinjari Md. K. Mohinuddin, Reddy B. Mohan, Sangita D. Kumar and Nallagondu C.G. Reddy

Volume 2 , Issue 2 , 2015

Page: [163 - 169] Pages: 7

DOI: 10.2174/2213346102666150205100538

Price: $65


Montmorillonite K-10 clay has been identified as an efficient and green catalyst for the synthesis of 2-amino-4-aryl thiazole derivatives (3) in good to excellent isolated yields (80-96%) from α-brominated aralkyl ketones (1) and thiourea (2) in aqueous medium at 25-30°C. The present procedure offers advantages of short reaction time, simple work-up, high yields of products and the catalyst is environmentally benign and exhibits remarkable reusable activity by four times.

Keywords: Montmorillonite K-10 clay, phenacyl bromides, thiourea, water, 2-amino-4-aryl thiazoles.

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