Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance

Title:Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance

Volume: 15 Issue: 4

Author(s): Shuaizhang Li, Wen Zhang, Xuejiao Yin, Shilai Xing, Heidi Qunhui Xie, Zhengyu Cao and Bin Zhao

Affiliation:

Keywords: ATP-binding cassette (ABC) transporter, cancer, inhibitors, multi-drug resistance, substrate.

Abstract: The ABC (ATP-binding cassette) transporter is one of the largest and most ancient protein families with members functioning from protozoa to human. The resistance of cancer and tumor cells to anticancer drugs is due to the over-expression of some ABC transporters, which may finally lead to chemotherapy failure. The mouse ABC transporters are classified into seven subfamilies by phylogenetic analysis. The mouse ABC transporter gene, alias, chromosomal location and function have been determined. Within the ABC super-family, the MDR transporters (Abcb1, Abcc1, Abcg2) in mouse models have been proved to be valuable to investigate the biochemistry and physiological functions. This review concentrates on the multidrug resistance of mouse ABC transporters in cancer and tumor cells.

Cite this article as:

Li Shuaizhang, Zhang Wen, Yin Xuejiao, Xing Shilai, Xie Qunhui Heidi, Cao Zhengyu and Zhao Bin, Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance, Anti-Cancer Agents in Medicinal Chemistry 2015; 15(4) . https://dx.doi.org/10.2174/1871520615666150129212723